Fighting Kidney Disease

The Prince of Wales Hospital Foundation is supporting the Prince of Wales Hospital in preventing kidney disease and creating better outcomes for those affected by the chronic illness

Chronic kidney disease (CKD) is a significant and growing public health issue, responsible for a substantial burden of illness and premature mortality. It can affect anyone:

• One in three Australians are at risk of CKD particularly, those with high blood pressure or diabetes

• 13.5% of Australians actually have CKD (>50% among those over 65y).

• CKD is a major risk factor for cardiovascular disease, acute kidney injury (AKI) and is the 5th commonest cause of death in Australia

• Survival with severe CKD is poorer than most cancers

• You can lose up to 90 % of kidney function before experiencing symptoms

• Less than 10 % of people with CKD know they have the condition – thus more than 1.5 million Australians are unaware they have CKD.

• Diabetes and high blood pressure, age over 60, Aboriginal or Torres Strait Islander origin, smoking and obesity are the main risk factors for CKD

• If chronic kidney disease is detected early and managed appropriately, then the rate of deterioration in kidney function can be reduced by up to 50 % and perhaps reversed

Prince of Wales Hospital Nephrology- A Centre for Excellence

The Prince of Wales Hospital Foundation is supporting the Prince of Wales Hospital Nephrology Department innovative new work and research into this vital area through exciting new initiatives. Headed by internationally renowned renal health clinician Professor Zoltan Endre, POWH has a dedicated multidisciplinary team of specialists who include nephrologists, transplant and access surgeons, anaesthetists, nurses, allied health ( social work, dietitians, pharmacists) and administration staff providing services for the Randwick Hospital campus. The POWH Nephrology Department also provides consultations for women at The Royal Hospital for Women and dialysis and transplant services for Children at Sydney Children’s Hospital. With more than 50 years of experience, POWH is the leading centre providing kidney transplant services for the East Coast of NS, including St George, Wollongong and Sutherland areas.

Prince of Wales Hospital Biobank- The Foundation for Future Innovation

The Prince of Wales Hospital Foundation is supporting the funding of the Prince of Wales Hospital Kidney Biobank.POWH is establishing the regions first unique kidney biobank for acute (AKI) and chronic kidney disease (CKD) and idiopathic nephrotic syndrome (INS). This biodepositry of patient tissue, samples and linked clinical data from patients with Kidney Disease will provide a strategic resource for fundamental, translational research and will open up a wealth of new opportunities for all researchers and industry to accelerate new advances to benefit kidney patients, their treatment and care.

Life Saving and Life Changing Research

Under the leadership of Prof Endre, the Department is conducting ground breaking research in:
• Early Detection of Acute Kidney Injury (AKI) after cardiac surgery
• Prediction of Progression of CKD
• Prediction of Transplant Outcome using Biomarkers
• Biomarkers of Kidney Drug Toxicity after Kidney Transplantation
• Biomarker Detection of Subclinical Kidney Disease
• Genomic Detection of Subclinical Kidney Disease to improve Graft Survival particularly after donation from extended criteria (marginal) kidney donors
• Real-time measurement of GFR in normal kidneys and in chronic kidney disease
• Measurement of Renal Reserve in kidney donors to predict transplant outcome
• Measurement of Renal Reserve to detect Subclinical Kidney Disease
• Mechanisms and modulation of Acute Kidney Injury (AKI)
• Biomarkers to predict recovery from Acute Kidney Injury (AKI)

Early Detection of AKI for Better Outcomes

Two vital projects in this area are underway and require urgent funding:

Early detection an intervention in Acute Kidney injury using eAlerts

This project is run in conjunction with hospital pathology services and uses laboratory eAlerts to automatically detect changes in serum creatinine to identify AKI. Funds are needed for IT development, data collection and for staff and patient education. When AKI is detected, the development of a care and information package will help patients understand AKI and be aware of the renal care services and support available at POWH.

Early detection of AKI using novel urinary and serum biomarkers In the Emergency Department. Novel urinary and plasma biomarkers will be measured on admission and 24 and 48 hours later to predict development of AKI in high risk patients, such as those with sepsis, acute cardiac failure, diabetic emergencies and acute coronary syndromes. These novel biomarkers detect AKI much earlier than creatinine, the current gold standard. Funds are needed to assist with sample and data collection, storage and analysis. The samples will also provide a resource for discovery of new biomarkers to guide management.

For further information, please contact:

Wendy Farrow, Director of Generosity, Prince of Wales Hospital Foundation

wendy@powhf.org.au / 0439 780 728